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CYP2D6 Metabolism and Pharmacogenomic Variability The liver converts hydrocodone to hydromorphone via CYP2D6 O-demethylation, producing an active metabolite with approximately 30 times higher mu-opioid receptor affinity than the parent compound

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5) in line with catalytic parameters described for enzymes active in the secondary metabolism 36

Okay, so second question is how did we first meet and what were our first impressions of each other